O59: USE OF DEXTRAN 40 FOLLOWING PANCREAS TRANSPLANT MAY REDUCE EARLY INFLAMMATION AND SIGNIFICANT BLEEDING COMPARED TO A HEPARIN-BASED PROTOCOL
نویسندگان
چکیده
Abstract Introduction Dextran 40 (D40) is a synthetic colloid with anticoagulant properties, which commonly used instead of heparin following pancreas transplantation, however there lack evidence over more effective. Graft thrombosis and pancreatitis, may be mediated through micro or macrothrombosis within the graft, remain significant complications transplantation. We hypothesised that D40 reduces inflammation its antithrombotic pro-microcirculatory effects. aimed to evaluate compared heparin-based protocol by comparing post-operative post-transplant levels inflammation. Method Data were collected retrospectively for transplant patients between December 2009 August 2018 – 26 had been treated pre-Dextran 37 received D40. Post-operative inflammatory markers (WCC, CRP amylase) on days 1, 2, 3 7 two groups. Potential confounders also recorded. Result Patients in group similar rates but less likely have substantial bleeding protocol. The who significantly lower WCC 7. differences remained when results adjusted - cold ischaemic time donor age. Conclusion appears as effective IV at preventing graft transplant, confer reduced risk bleeding. It reduce processes, leading pancreatitis. Take-home message Using an after transplantation thromboses has
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ژورنال
عنوان ژورنال: British Journal of Surgery
سال: 2021
ISSN: ['1365-2168', '0007-1323']
DOI: https://doi.org/10.1093/bjs/znab117.059